MOLECULAR ADAPTATION RESPONSE OF IMMUNITY SYSTEM ON POPULATION EXPOSED TO AIR POLLUTION

Abstract

Background: Industry in various regions of the world has been very influential with the emissions of various substances that are air pollutants and increase air pollution. Continuous exposure to air pollution can lead to  decrease the immune system. The purpose of this research is to know the molecular response of immunity of body residing in environment exposed to air pollution.

Method: The type of this research is observational analytic by using cross sectional approach. The sample of this study amounted to 60 people living around the Rubber Factory Gandus and TPA Sukawinatan garbage Palembang. Examination of TNF-α and IL-6 levels using ELISA Human kit technique. Measurement of H2S at a distance of 250 meters, with methylene blue method.

Result: H2S levels in the area around the Sukawinatan Wastewater Disposal (0,428 ppm) are higher than in the Gandus Rubber Factory ( 0,332 ppm). There was no significant difference between mean of TNF-α level (p=0,701) and mean of IL-6 level (p=0,618). The correlation values of respondent characteristics with TNFα and IL-6 levels in the two study sites were very weak and not statistically significant. The correlation value between IL-6 is very weak and statistically significant around the Gandus Rubber Plant (r=0.284; p=0.128) and around the Sukawinatan waste disposal site (r=-0.258; p=0.169).

Conclusio: Even though H2S levels in the area around the Sukawinatan Wastewater Landfill are higher than in the Gandus Rubber Factory, it is expected that the residents who are around rubber and waste landfill sites use personal protective equipment such as masks when outside the house and keep their nutritional intake well so that the immune system is awake.

Keywords: Hidrogen sulfida, tumor necrosis factor-alpha, interleukin-6

https://doi.org/10.26553/jikm.2018.9.2.150-160